Introduction: Diffuse axonal injury is a type of severe head injury. In overall head injury cases, it is estimated that 60% of severe head injuries and 40% of head injury cases were associated with diffuse axonal injury. Diffuse axonal injury is found in secondary brain injury with the occurrence of an ischemic brain. Magnesium sulfate plays a role as a deciphering agent in severe head injury and ischemic brains. This study was conducted to investigate the efficacy of magnesium sulfate administration in patients with diffuse axonal injury.
Methods: This research was conducted using a quasi-experimental design for three months, from October to December 2019, involving patients with severe head injury admitted to the emergency room of Dr. M. Djamil General Hospital, Padang.
Results: The results showed that magnesium sulfate administration was more effective than conventional therapy in improving the level of consciousness of patients with severe head injuries, but there was no significant difference between the two groups (p > 0.05). The number of patients was equally analyzed between the two study groups using independent t-test analysis on SPSS.
Conclusion: Magnesium sulfate administration was more effective than conventional therapy, but the difference was not statistically significant. Age and onset must be considered by researchers to assess the performance of magnesium sulfate therapy in diffuse axonal injury patients.
Â Keywords: diffuse axonal injury, magnesium sulfate, severe head injury