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Scaffold in tissue engineering for neuroregeneration and neural repair following traumatic brain injury: A review

  • Yudi Yuwono Wiwoho ,
  • Nurhadi Ibrahim ,

Abstract

Background: Traumatic brain injury (TBI) is a leading cause of working-age disability worldwide. Despite efforts to develop neuroprotective treatment approaches, meaningful progress in brain regeneration has remained elusive. Due to the brain's limited regenerative potential, treating TBI is difficult. Tissue engineering is needed to support nerve growth, guide neurite extension, and rebuild brain tissue.

Literature review: Despite limited evidence, many novel bioscaffold research in recent decades gives new hope to neuroregeneration and is continuously done to achieve a paramount strategy for regenerative medicine. This article reviewed several manuscripts about bioscaffold material and techniques that potentially improve neural repair in TBI. Therefore, this article highlights momentum studies in bioscaffold design and neuronal structure.

Conclusion: Unrestricted tissue repair is limited in the central nervous system, although tissue engineering techniques to tackle molecular and physical challenges from brain injury are being developed. Bioengineering provides economically accessible treatments for tissues including skin, bone, and cartilage; nevertheless, there is no approved bioengineering treatment to repair CNS lesions at the moment.

Keywords: biomaterial, neuroregeneration, scaffold, traumatic brain injury, tissue engineering

How to Cite

Wiwoho, Y. Y., & Ibrahim, N. (2024). Scaffold in tissue engineering for neuroregeneration and neural repair following traumatic brain injury: A review. Indonesian Journal of Neurosurgery, 7(1), 32–38. https://doi.org/10.15562/ijn.v7i1.258

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Yudi Yuwono Wiwoho
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IJN Journal


Nurhadi Ibrahim
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IJN Journal